Yes, but only with music via cable, and noise reduction will not be active. As soon as you insert the charging cable micro-usb plug, the Bluetooth and NC functionalities will be switched off, and they cannot be reactivated unless you remove the charging cable, and there must of course be a charge in the battery. If you listen to cabled music while charging, be prepared to hear noise under certain conditions. Both computers and switch-mode power supplies can be very noisy, and this noise can sometimes be heard as a whine or buzz. This can only be eliminated by using a power supply that does not create noise.